Alloxan has been used to produce diabetes in experimental animals by destroying the insulin-secreting islet cells of the pancreas. alloxan An oxygenated pyrimidine derivative, which is a toxic glucose analogue that induces experimental diabetes by selectively destroying pancreatic beta cells by superoxide production.induction of diabetes (150 mg/kg, of alloxan, i.p.). Aqueous extract of P.edulis (AEPE) at a dose of 200 mg/kg, p.o was administered as single dose per day to diabetes-induced.
Periodontal disease in diabetic patients presents higher severity and prevalence; and increased severity of ligature-induced periodontal disease has been verified in diabetic rats. However, in absence of aggressive stimuli such as ligatures, the influence of diabetes on rat periodontal tissues.Purpose. This study evaluated the long-term effects of alloxan-induced diabetes in rat liver. Methods. Thirty nondiabetic control rats (NC) and 30 untreated .