Scientific achievements continue to set new standards in terms of the scale at which experimentation is possible. A recent National Aeronautics and Space Administration (NASA) mission, which aimed to capture specimens from a comet for analysis, highlights the magnitude of scale and precision achievable by modern science.
Beiging of white adipose tissue has potential antiobesity and antidiabetes effects, yet the underlying signaling mechanisms remain to be fully elucidated. Here we show that adipose-specific knockout of Rheb, an upstream activator of mechanistic target of rapamycin complex 1 (mTORC1), protects mice from high-fat diet–induced obesity and insulin resistance.