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Original Article from The New England Journal of Medicine — Clinical Study of Daunomycin and Prednisone for Induction of Remission in Children with Advanced Leukemia.We hypothesized that insulin resistance may be involved in the pathogenesis of obesity-related elevations in ECs, which predicts a direct effect of insulin on ECs. We observed that 24-h insulin treatment reduces intracellular AEA (P 0.05) and 2-AG (P 0.05) in 3T3-L1 adipocytes. To further understand the impact of insulin, we examined.